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Boris, a 62-year-old retired contractor, is undergoing surgery to repair an umbilical hernia. He has had Parkinson’s disease for 5 years and is currently taking levodopa-carbidopa (Sinemet CR) and selegiline. He has enjoyed good control up until this week but is now experiencing more “bad times,” as he calls them. His physician has changed his therapy to include entacapone. 1. Patients who are taking long-term levodopa treatment often experience an “on-off” phenomenon in symptoms. Explain the physiology behind this phenomenon. 2. Explain the reason for giving selegiline along with the levodopa-carbidopa. 3. Are there any concerns regarding drug interactions? Explain your answer. 4. What is the purpose of the entacapone? 5. Before administering the entacapone, the nurse reviews Boris’s history for any potential contraindications. What condition(s) would be a potential contraindication to entacapone?
SCIENCE
HEALTH SCIENCE
NURSING

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