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The patient has been taking an oral dose of drug X at a dose and dosing interval that resulted in a therapeutic steady state plasma concentration for the last several weeks. This week the level of drug X in the patient’s blood dropped below therapeutic levels. Which of the following statements could explain this finding:Â

A. The patient has been started on a second drug that inhibits P-glycoproteinÂ

B. The patient has been started on a second drug that inhibits CYP450 enzymesÂ

C. The patient has been started on a second drug that competes with drug X for renal tubular secretionÂ

D. The patient has been started on a second drug that induces CYP450 enzymes

SCIENCE
HEALTH SCIENCE
NURSING
NURS 531

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